I personally like 2x22 best, with 1x22 being runner up. But, god, I remember the anxiety when we didn't know if the show was going to get picked up after season 1, and how I thought that it couldn't possibly end like this. I was a mess.

*cuddles and feeds your Dean/Castiel/Balthazar plotbunny* Such a nice little fellow. Please be taking good care of him, 'kay? And his brothers as well.